YuLi Chai et al. (Oncogene. 1999; 18: 263-268) reported the existence of
an interaction between the cellular tumor antigen p53 and the breast
cancer type 1 susceptibility protein BRCA1, showing the involvement of
the "central" region of p53 (a.a. 99-307) and the 2nd BRCT domain of
BRCA1 (a.a. 1760-1863).
With our methods, we were able to predict correctly the interacting
domains of p53 and BRCA1, finding with greater precision the regions
involved in the interaction.
Interaction of p53 with BRCA1
